Abstract
Purpose.
 Alveolar osteitis is the most common post-odontectomy complication. Although blood clot disintegration is known to be the cause of the condition, an agreement is lacking regarding a treatment of choice. The aim of the current study therefore was to evaluate major autohemotherapy as one treatment method.
 
 Patients and Methods.
 A total of 183 patients were categorized into 4 groups (I, II, III, and IV) according to pain severity (mild, moderate, severe, or agonizing, respectively). Major autohemotherapy was performed for all patients by withdrawing 225mL of patient's blood and mixing them with 225mL of Oxygen-Ozone gas (where Ozone concentration was 50µg/mL gas)
 
 Results and Discussion.
 Despite AHT was a high-potency curative treatment for groups I and II, it was palliative for group IV. For group III, it oscillated between being a curative or a palliative treatment with a statistically insignificant difference.
 
 Conclusion.
 AHT might be a recommended treatment for AO
Highlights
Alveolar osteitis (AO) is a very common complication of dental extraction [1]
Patients diagnosed with AO (“dry socket”) fulfilling inclusion criteria were divided into 4 groups according to pain severity (Table 1)
A total of 183 patients were included in the current study
Summary
Alveolar osteitis (AO) is a very common complication of dental extraction [1]. Birn’s suggestion [2] that AO results from blood clot disintegration has gained wide acceptance, the exact etiology is still poorly understood [3,4]. Pain is the most important aspect of AO according to Fazakerlev and Field [5], and a variety of treatment methods have been attempted to treat or alleviate this pain, considerable controversy exists regarding their relative efficacies [3,6,7]. Ozone is a very powerful healer and oxidant [8,9,10,11,12,13]. Since Wolff has introduced Ozone major Autohemotherapy (AHT) was a frequently used treatment method for a variety of conditions [14]. AHT enhances oxygen delivery to ischemic tissues, and in turn, improves general metabolism and activates the immune system as well; therefor it is a powerful healing treatment modality [8,9,10,11,13]
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