Abstract
Developments in levodopa formulations and the standardisation of deep brain stimulation (DBS) substantially improved clinical management of patients with Parkinson's disease before the turn of the century. As a result of these developments, Parkinson's disease has become a chronic disorder and it is associated with a plethora of non-motor disabling complications. Cognitive impairment is now a major complication of Parkinson's disease.1 Patients gradually develop from being cognitively normal, to having mild cognitive impairment and then dementia as part of a continuum of progressive pathological changes in the brain, including misfolded protein deposition and neuronal loss.
Published Version
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