Abstract
Background: In Bangladesh, the prospect of using homograft is immense. However, homograft banking is not available in this country until now. The aim of this study was to evaluate the processing, preservation and banking of aortic homograft from human cadaver in Bangladesh. Material & Methods: This observational study was conducted in Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh from July 2016 to June 2018. The study included 30 procured hearts from adult unclaimed deceased individuals, who underwent autopsy within 24 hours of death at the Department of Forensic Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh, were categorized into two groups: group-A: 15 homograft valves prepared as Aortic Sleeve (AS), and group-B: 15 homograft valves prepared as Aortic Conduit (AC). Results: The Mean ± SD age in Group-A and Group-B was 34.27 ± 8.16 years and 34.20 ± 8.22 years, respectively. Gender distribution in Group-A included 11 (73.33%) males and 4 (26.67%) females, while Group-B had 12 (80%) males and 3 (20%) females. Morphological abnormalities were minimal, with 1 (6.67%) valve in Group-A and 2 (13.33%) in Group-B showing leaflet incompetency. Microbiological analysis revealed statistically significant differences in contamination rates before antibiotic treatment (p<0.05), while after antibiotic treatment, both groups demonstrated effective decontamination. Cryopreservation exhibited a 100% success rate in maintaining sterility, with no instances of contamination in both groups (p>0.05). Conclusions: The current study concludes that it is possible and effective to procure aortic homograft from human cadaver for aortic replacement surgery.
Published Version
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