Abstract
Tissue engineering or tissue reconstruction/repair/regeneration may be considered as a guiding strategy in oral and maxillofacial surgery, as well as in endodontics, orthodontics, periodontics, and daily clinical practice. A wide range of techniques has been developed over the past years, from tissue grafts to the more recent and innovative regenerative procedures. Continuous research in the field of natural and artificial materials and biomaterials, as well as in advanced scaffold design strategies has been carried out. The focus has also been on various growth factors involved in dental tissue repair or reconstruction. Benefiting from the recent literature, this review paper illustrates current innovative strategies and technological approaches in oral and maxillofacial tissue engineering, trying to offer some information regarding the available scientific data and practical applications. After introducing tissue engineering aspects, an overview on additive manufacturing technologies will be provided, with a focus on the applications of superparamagnetic iron oxide nanoparticles in the biomedical field. The potential applications of magnetic fields and magnetic devices on the acceleration of orthodontic tooth movement will be analysed.
Highlights
Pathogenic bacteria present in dental plaque could enter into the bloodstream and their metabolites/derived molecules pass through the blood–brain barrier (BBB), after negatively affecting its permeability, and reach the brain, promoting an increase in the levels of inflammatory cytokines, and cell and vascular adhesion molecules [10]
We look towards magnetic fields effects and potential applications on the acceleration of orthodontic tooth movement
The purpose of this work is to provide an overview of current strategies and innovative technological approaches in tissue engineering, trying to offer some information regarding the available scientific data and practical applications in the field of oral and maxillofacial repair strategies
Summary
Various dental diseases including congenital defects, tooth loss, or trauma affect more than 3.9 billion people [1], making necessary intervention related to tissue repair or reconstruction to restore oral or maxillofacial functionalities [2,3]. Pathogenic bacteria present in dental plaque could enter into the bloodstream and their metabolites/derived molecules pass through the blood–brain barrier (BBB), after negatively affecting its permeability, and reach the brain, promoting an increase in the levels of inflammatory cytokines, and cell and vascular adhesion molecules [10] In this scenario, an intriguing strategy towards the development of 3D multifunctional hybrid structure combined with active/antibacterial systems and magnetic stimulation could improve periodontal tissue prevention and treatment or repair. We look towards magnetic fields effects and potential applications on the acceleration of orthodontic tooth movement In this scenario, an important thought towards the development of 3D multifunctional hybrid structure combined with active/antibacterial systems and magnetic stimulation could improve periodontal tissue prevention and treatment or repair
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