Abstract
A simple analytical model is presented which enables rapid interactive prediction and control of magnetically labelled cells in an arterial bifurcation using magnetic field gradients produced by a magnetic resonance imaging (MRI) system. This model is compared against experimental results for human mononuclear cells labelled with micrometre sized superparamagnetic iron oxide particles. Experimental and theoretical results highlight the importance of cell aggregation for magnetic targeting in a strong magnetic field. These predicted aggregates are confirmed via confocal endoscopy which allows the visualization of cell aggregates and their movement inside a vascular flow model in a 9.4 T preclinical MRI scanner.
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