Abstract
SummaryAim - To correlate the magnetic resonance imaging signal changes observed during interstitial laser photocoagulation (ILP) therapy with histopatho-logical analysis of tissue necrosis. A 1.5T MR system was used. Lesions were produced with a diode laser (805 nm) in the liver of normal Wistar rats at laparotomy under general anaesthesia and imaged during treatment. Seventeen lesions were monitored with a T1-weighted spin echo (T1WSE) sequence, and 15 with a FLASH sequence. Treated tissue was removed and stained for NADPH-diaphorase to determine the extent of devitalization. Per-procedural T1WSE showed an expanding area of low signal which developed a high signal rim as ILP progressed. FLASH imaging showed an expanding area of low intensity which was replaced by a complex region of signal change as treatment progressed. Good imaging-histopathological correlation was shown: for T1WSE, r2=0.88 (P < 0.001) and for FLASH, r2=0.95 (P < 0.001). MR imaging during hepatic ILP accurately shows the extent of tissue necrosis and therefore may become clinically useful in the control of interstitial thermal treatments to liver lesions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
