Abstract

Objective To explore the application of Magnetic Resonance Imaging(MRI) T1 weighted inversion recovery(T1WIR) sequence in evaluation of brain development in infants. Methods A total of 28 infants who accepted MRI examination of brain in West China Second University Hospital, Sichuan University from March to June 2014 were chosen as study subjects.Every infant was underwent both T1WIR and T1 weighted spin echo (T1WSE) sequence in brain transverse axial scanning to evaluate brain development.All MR images were evaluated and scored(0-3) about myelination by two roentgenologists independently.Images with score of 3 can clearly display myelination.Consistency test was made for the scores between these two roentgenologists.Kappa value was calculated and all scores were underwent rank sum test.Contrast ratio (CR) of grey matter-to-white matter was calculated in both T1WIR and T1WSE sequence.Intensity decreased ratio of T1WIR-to-T1WSE was also calculated in both grey matter and white matter.CR of the two sequences, intensity decreased ratios of grey matter and white matter were all underwent paired t-test. Results ①MR image scores about myelination between the two doctors was consistent(u=7.887, P=0.000)and with a comparatively satisfactory consistent degree(Kappa value=0.792). MR image score about myelination of T1WIR sequence in 28 infants was higher than that of T1WSE sequence, and the difference was significantly(3 points vs 2 points, Z=3.64, P=0.000). ②CR of T1WIR sequence was higher than that of T1WSE sequence, and the difference was significantly[(0.26±0.06) vs (0.05±0.02), t=16.544, P=0.000]. According to T1WSE sequence, intensity decreased ratio of grey matter in T1WIR sequence was lower than that of white matter, and the difference was significantly[(2.03±0.83) vs (2.25±1.26), t=2.616, P=0.014]. Conclusion T1WIR sequence of MRI can substitute T1WSE sequence in evaluation of brain development in infants. Key words: Brain; Magnetic resonance imaging; T1 weighted inversion recovery sequence; T1 weighted spin echo sequence; Growth & development; Infant

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