Abstract
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inheritedmicroangiopathy caused by mutations in the Notch3 gene. Typical findings from magnetic resonance imaging (MRI) includemultiple subcortical lacunes, extensive white matter change and multiple cerebral microbleeds (CMBs). Whereas MRI findings arewell described in Caucasian patients with CADASIL. There is a paucity of data on Asian patients. We aim to characterizedimaging findings in Asian patients with CADASIL. The study population comprised 73 patients who underwent brain MRI betweenMarch 2012 and May 2013. T1-weighted image, susceptibility weighted image (SWI), and fluid attenuated inversion recovery(FLAIR) images were analyzed by visual inspection. Clinical information at time of imaging was available for all patients. Themean age of patients (44 men, 29 women) was 63.2±11.8 (SD). In patients with CADASIL, lacunes (76.7%, 56 of 73), CMBs(74%, 54 of 73), and area of white mater hyperintensities (98.6%, 72 of 73) were observed. Lacunes, CMBs, and WMHs werelocated predominantly in the cortical-subcortical lesion (57.5%, 54.8%, and 98.6%, respectively). These findings suggest thatcortical-subcortical area is the most frequently injured area of brain in CADASIL. Further studies are needed to validate ourfindings.
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