Abstract
Magnetic nanoparticles represent emerging tools in biomedical and pharmaceutical research. Because in most cases, the surfaces of these nanoparticles are hydrophobic, surface modifiers are usually applied to stabilize the colloidal suspension in an aqueous media. This investigation reports a simple technique for the preparation of MnFe2O4 synthesized within polyvinylamine (PVAm) nanoparticle reactors. Magnetite nanoparticles were previously synthesized using a similar scheme; however, substituting MnFe2O4 for Fe3O4 improved nanoparticle magnetization properties and further established the synthetic approach. PVAm nanoparticles exhibited more than 18% manganese ferrite loading by weight, a saturation magnetization of ∼ 40 emu/g of MnFe2O4, excellent colloidal stability, and reactive primary amines for possible drug conjugation or surface modification. Transmission electron micrographs revealed that the dispersions contained ∼ 50 nm PVAm nanoparticles incorporating manganese ferrite particles with a size less than ∼ 7 nm. This reaction scheme further justifies a unique synthetic methodology for magnetic nanoparticles offering potential use in contrast-enhanced magnetic resonance imaging or drug delivery. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 991–996, 2010
Published Version
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