Magnetic mesoporous silica material (Fe3O4@mSiO2) as adsorbent and delivery system for ciprofloxacin drug

Abstract

Magnetic mesoporous materials covered with mesoporous silica shells (Fe3O4@mSiO2) are the most promising material, which is fulfilling many applications especially for adsorption and delivering drugs system. The present research involves the preparation of magnetic nanoparticles Fe3O4 and mesoporous silica mSiO2 as coreshell materials using sol–gel method in the presence of amid propyl betaine surfactant as template. The surface texture, morphology and particle and crystalline size of the prepared adsorbent were characterized using SEM, TEM, XRD, and nitrogen adsorption–desorption techniques. The results show that the prepared adsorbent has surface area equal to 1670 m2/g, mesopores in range 2-10 nm with a high degree of ordering of the porous structure and has a crystalline size equal to 30.16 nm. The adsorption behavior of Ciprofloxacin drug from aqueous systems onto the adsorbent has been studied using a batch experiments method. The equilibrium of the process at temperature 293K was achieved within 120 min and 0.06 g of adsorbent dose. Adsorption isotherms were fitted with the Langmuir, Freundlich, Temkin, and Dubinin –Radushkevich models and the results show the Langmuir and Temkin model was best fitted, and the adsorption process is physical adsorption type. The kinetic data were analyzed and found to match well with pseudo-second order kinetic model. Ciprofloxacin drug loading and capacity of release of the Fe3O4@mSiO2 carrier was also studied.