Magnetic Hyperthermia with biocompatible coated nanoparticles: A temperature analysis

Abstract

The magnetic nanoparticles (MNPs) having the special (magnetic and thermal) properties are promising for Magnetic Hyperthermia. To increase their biocompatibility, these MNPs are covered by different organic shells as: chitosan, oleic acid or silica. When an external time - dependent magnetic field is applied, the temperature developed within a malignant cell is strongly influenced by the type of the material which covers the magnetic nanoparticle. This paper studies the temperature field induced by the MNPs covered by an organic shell within a concentric tissues configuration (malignant and healthy tissues). The shell thickness influences significantly the temperature field developed within a malignant tissue. These important effects should be considered in the computation of the specific particle doses corresponding to the hyperthermia treatment.