Abstract
Disassembling microtubules provide forces that drive chromosomal movement in dividing cells. This motion can occur independently of conventional motor activity, and instead relies on the tenacious coupling of kinetochores to dynamic microtubule tips. During microtubule disassembly, kinetochores maintain load-bearing tip attachments even as thousands of tubulin subunits are lost from the tip per second. Despite recent advances in our structural and functional understanding of kinetochores and microtubules, it remains unknown how these molecular machines sustain such persistent attachments.
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