Abstract
Magnesium sulfate was given intravenously to eight cats with recording electrodes permanently implanted in the brain. The MgSO4 caused marked behavioral changes; yet, brief amplitude depression aside, cortical and subcortical electrical activity remained unchanged. Small doses of MgSO4 (25 mg/kg) caused retching only; larger doses (50 and 75 mg/kg) produced muscle paralysis and respiratory depression. Even so, there were no electroencephalographic signs of sedation or narcosis. Any anesthetic or analgesic action of magnesium is overshadowed by its neuromuscular blocking effect.
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