Abstract
MAF1 sequesters mitochondria for Toxoplasma gondii.
Highlights
Mitochondria, the powerhouses of eukaryotic cells, regulate many pathways related to cell growth and division
As they report in their paper published this month in PLOS Biology, Lena Pernas, John Boothroyd, and colleagues have brought us closer to understanding the mechanism used by T. gondii to sequester host cell mitochondria
To determine if mitochondrial association factor 1 (MAF1) really does mediate host mitochondrial association (HMA), Pernas and coworkers genetically engineered type II parasites to express the version of MAF1 found in the type I strain
Summary
Mitochondria, the powerhouses of eukaryotic cells, regulate many pathways related to cell growth and division. The protozoan Toxoplasma gondii is a parasite that resides within intracellular vacuoles inside host cells. Some strains of T. gondii can corral and sequester their host’s mitochondria together at the vacuole—a process termed host mitochondrial association (HMA).
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