Abstract
Vitamin and cofactor acquisition in apicomplexans: Synthesis versus salvage
Highlights
Determined by nutrient availability, they either use their cells and in a vacuole connected to the host cell via an biosynthesis machineries or largely depend on their host extensively folded membrane structure called the feeder for metabolite acquisition
Plasmodium falciparum is the deadliest form of the human malaria parasites that proliferate in erythrocytes and hepatocytes
thiamine pyrophosphate (TPP) acts as a cofactor for enzymes implicated in carbohydrate and amino-acid metabolism such as the pyruvate dehydrogenase (PDH) complex, 2-oxoglutarate dehydrogenase (OGDH), pyruvate decarboxylase (PDC) and dihydrolipoamide dehydrogenase (DLD)
Summary
Determined by nutrient availability, they either use their cells and in a vacuole connected to the host cell via an biosynthesis machineries or largely depend on their host extensively folded membrane structure called the feeder for metabolite acquisition. We review the progress made in T. gondii and apicomplexans in general, to better understand of the interrelationship of de novo synthesis and scavenge routes for vitamins and cofactors, and their utilisation in different life-cycle stages. All apicomplexans possess the enzymes for the subsequent conversion into NAD+ and NADP+, the corresponding genes appear dispensable for T. gondii tachyzoites, based on their FS (NAD+ synthase, +0.03 and NAD+ kinase, -1.33) (Fig. 3).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
