Abstract
Results The average age at disease onset was 29 months (range, 3– 135 months). There were 43 females (33.3%) and 26 (20.2%) males. Eight children (12%) were non-responders to the first IVIG infusion. Nine children (13%) had coronary alterations (ectasia or aneurysms). Statistical analysis for MIF genotyping did not show significant differences between patients and controls, both for allelic and genotypic frequencies. However KD patients carrying a MIF -173*C allele developed CAA more frequently than those without these alleles (7/9 77.8% vs 16/44 26.7%, p < 0.005) and the MIF -173*CC homozygosis resulted more frequent in children with CAA than those without (2/9 CC 22.2% vs 2/60 CC: 3.3%, p < 0.004). Moreover, non-responders to a single IVIG infusion carried the MIF 173*C allele more frequently than responders (6/8 = 75% vs 17/61 = 28%, p < 0.014).
Highlights
MIF is a proinflammatory cytokine regulator of host inflammatory and immune responses, and is expressed by many different cells types
15th Paediatric Rheumatology European Society (PreS) Congress Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
Serum levels of MIF have been found to be increased in several inflammatory diseases, Kawasaki disease (KD) included
Summary
Address: A Meyer Children's Hospital, Florence, Italy * Corresponding author from 15th Paediatric Rheumatology European Society (PreS) Congress London, UK. 14–17 September 2008. Address: A Meyer Children's Hospital, Florence, Italy * Corresponding author from 15th Paediatric Rheumatology European Society (PreS) Congress London, UK. Published: 15 September 2008 Pediatric Rheumatology 2008, 6(Suppl 1):P256 doi:10.1186/1546-0096-6-S1-P256. 15th Paediatric Rheumatology European Society (PreS) Congress Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
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