Abstract
Introduction: The macrophage-inducible C-type lectin Mincle has recently been identified as pattern recognition receptor sensing mycobacterial infection via recognition of mycobacterial cell wall component trehalose-6',6-dimycolate (TDM). Recently, we characterized an important role for Mincle in regulating lung protective immunity against pulmonary M. bovis BCG infection in mice. At the same time, we observed that Mincle KO mice were more susceptible to intravenous mycobacterial infection than wild-type (WT) mice. However, the role of Mincle in systemic mycobacterial infections has not been examined so far.
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