Abstract
A three-step method for the synthesis of new 18, 21 or 24-membered macrocyclic tetralactams with two dimethyleneoxy moieties is described. The method consists in the ring closure of a bis-secondary amine with a diamide diacid activated by the thiazolidine-2-thione group. The cyclization does not require high dilution techniques and provides the expected tetralactams in good yields, ranging from 42% to 73%. This synthetic pathway leads to dissymmetrical or symmetrical molecules with substituents of variable lipophilicity.
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