Machine learning based prioritisation of osteoarthritis joint damage associated genes using skeletal genetics and genomics

Abstract

Purpose: Animal models are widely used in the study of osteoarthritis to investigate the effect of genetic or transient gene modulation on joint damage phenotypes. We recently described a knowledge base of gene modulations in osteoarthritis animal models, OATargets, that details the effect of 485 uniquely modulated genes (“OA genes”) in 661 publications published over the last 20 years. We continue to update and add new data types to this knowledge base to aid prioritisation of future laboratory investigation and suggest drug potential targets for osteoarthritis.