How to establish an expected animal model of post-traumatic osteoarthritis?

Abstract

Abstract Background Animal models of osteoarthritis (OA), including post-traumatic osteoarthritis and spontaneous osteoarthritis, have been established in many ways. In recent years, there have been many reports in various foreign academic journals, but animal models of post-traumatic osteoarthritis (distinct from spontaneous osteoarthritis) have rarely been established or summarized in these reports. Animal models of post-traumatic osteoarthritis show different characteristics depending on the animal species and modeling methods used, which is why we have written this article. Objective To summarize the research progress and research status of animal models of post-traumatic osteoarthritis. Methods A retrospective review of the animal model of post-traumatic osteoarthritis (OA) was conducted on the basis of reports retrieved from the PubMed database with the keywords for searching “animal model, post-traumatic osteoarthritis (PTOA)” from October 2006 to October 2016 and confided English language. A total of 80 academic articles on the study of animal models of traumatic osteoarthritis were retrieved, and 34 of them were included in this literature review after reading the free full-text of them. Results Different PTOA models based on different modeling methods and different animal species had their own characteristics. Different modeling methods should be selected according to different modeling animals. Conclusions Considering the project funds, experimental objectives and technical conditions, appropriate experimental animal and modeling method should be selected based on synthetic considerations to obtain an appropriate PTOA model and ideal experimental results.