Abstract
Hearing starts with the deflection of the hair bundle, a cohesive tuft of actin-based cylindrical protrusions—the stereocilia—that gives their name to the mechanosensory hair cells of the inner ear. Tension changes in tip links interconnecting the stereocilia modulate the open probability of ion channels located at the stereociliary tips, resulting in an electrical response. Hair cells are tuned to a characteristic frequency of the stimulus and spatially distributed in auditory organs according to a tonotopic map.
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