Abstract
Curative surgical resection is the treatment of choice for early-stage and locally advanced non-small cell lung cancer (NSCLC). Locoregional N1 and N2 lymph nodes (LNs) are a site of tumor antigen presentation and T- and B-cell activation. They are removed during curative anatomic resection and provide a snapshot of the immune cell composition at the time of lymph node removal. While tumor bearing lymph nodes have been thoroughly investigated in NSCLC, little is known about the role of tumor-free lymph nodes.
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