Abstract
Human Bone Morphogenetic Proteins (BMP) are a group of bone inductive proteins that determine and form the human skeleton. In the adult, they reform bone after osteoclastic resorption as part of the normal bone turnover cycle. The concentration of BMP in human and animal bone is exceedingly small negating its clinical usefulness for bone induction via xenogenic or allogenic bone grafts. However, molecular biotechnology has cloned the BMP-2 genes to produce clinically effective concentrations in a recombinant form.
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