Abstract
Cardiomyopathy is a major cause of death in Duchenne muscular dystrophy (DMD) and several of the limb girdle muscular dystrophies (LGMD). Here we have examined the development of cardiomyopathy in the dystrophin deficient mdx mouse, a model for DMD, and the delta-sarcoglycan deficient Scgd−/− mouse, a model for LGMD2F by magnetic resonance imaging (MRI). MRI generates high-resolution anatomical images that can provide functional data on the mouse heart and therefore offers an important opportunity to study underlying mechanisms of cardiomyopathy in vivo.
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