Abstract
ACE-031 is a fusion protein derived from the extracellular domain of the human activin receptor type IIB (ActRIIB) linked to the Fc portion of human IgG1. ACE-031 binds with high affinity to GDF-8 (myostatin) and other negative regulators of muscle mass. In numerous nonclinical studies using normal animals and various disease animal models, treatment with a soluble ActRIIB fusion protein results in increased lean mass and decreased adiposity. Pharmacologic responsiveness to ACE-031 has been observed in several species including non-human primates.
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