Abstract
Aim: We have shown that LDL aggregated either mechanically by vortexing or enzymatically by sphingomyelinase (SMase-LDL) is internalised by macrophages and oxidised in lysosomes by redox active iron. We have now studied the effects of lysosomal oxidation of LDL on various lysosome-associated functions and also shown how the lysosomotropic antioxidant cysteamine is able to prevent these effects.
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