Abstract
Lysophosphatidic acid (LPA), the structurally simplest of the glycerophospholipids, is a potent second messenger whose functional diversity makes it a compelling target in lipid research. LPA, the effects of which include cell motility and proliferation, platelet activation, fertility and development, and neuropathic pain, is believed to act through a family of G protein-coupled receptors (GPCR). Since some members of this family of proteins are localized in ordered lipid domains (membrane rafts), a role for LPA in altering and re-ordering membranes as part of regulation of the signaling pathway cannot be discounted.
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