Abstract
Objective: Lynch syndrome (LS) increases the lifetime risk of endometrial cancer by about 40%–60%. Universal screening with microsatellite instability (MSI) and/or immunohistochemistry (IHC) for mismatch repair (MMR) proteins have been recommended. However, IHC for MMR proteins is less expensive and more available in most centers. If expression of any MMR proteins is absent, the patients should be offered genetic counseling and genetic testing. MMR IHC screening is not yet recommended in all endometrial cancer patients in Thailand. This study aims to evaluate the prevalence of MMR-deficient and germline MMR mutation in Thai endometrial cancer patients.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
