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Abstract
SINCE the discovery1 of the herpes-like virus particle (EBV) in cell cultures of Burkitt's lymphoma, the virus has been found in many (but not all) lymphoid cell cultures derived from patients with Burkitt's lymphoma2 and other lymphoid neoplasms3 or infectious mononucleosis4 as well as from normal individuals5. The virus has also been found in some biopsies of Burkitt tumours6. Serological evidence has implicated it as a causal or associated agent in heterophile-positive infectious mononucleosis7, 8, although its relationship to Burkitt's lymphoma is less clear. Antigenic studies suggest a relationship between the herpes-like virus and antigens detected by indirect immunofluorescence (IF) techniques in fixed cells9, surface antigens on viable cells10 and complement-fixing (CF) antigens in extracts of Burkitt cell cultures11.
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