Lymphoglandular bodies as useful morphological clue in diagnosis of Lymphoid malignancies- A Case Report

Abstract

Lymphoglandular bodies, observed as round basophilic cytoplasmic fragments on Giemsa stain, are linked with lymphoid malignancies, aiding in distinguishing lymphomas from other small round cell tumors. This case report underscores the diagnostic significance of Lymphoglandular bodies in Acute lymphoid leukemia diagnosis through bone marrow biopsy. We present a case of a 21-year-old male with chest pain and weakness. The bone marrow biopsy revealed a monomorphic cell population with a high nuclear cytoplasmic ratio, prompting immunomarker analysis that confirmed the presence of blasts as lymphoblasts, leading to the diagnosis of Acute lymphoid leukemia. The identification of Lymphoglandular bodies in bone marrow biopsy facilitated the diagnosis, as peripheral blood examination did not indicate the presence of blasts suggestive of leukemia. Literature on the role of Lymphoglandular bodies in lymphoma diagnosis is limited, with more emphasis on cytological preparations. Lymphoglandular bodies serve as an adjunct in differentiating between lymphoma and non-lymphoma malignancies, being more frequently associated with Malignant lymphoma. The study aim to prove Lymphoglandular bodies as useful morphological clue in diagnosis of Lymphoid malignancies.