Abstract
Forty-one patients with Hodgkin's disease have been investigated, mostly at their clinical presentation and, on frequent occasions, throughout the clinical course of their disease. A quantitative radioisotopic investigation has been made of the response of the patients' peripheral blood lymphocytes to PHA stimulation. It has been shown that lymphocyte response (lymphocyte transformation) is related to the severity of the disease; at presentation, the majority of patients with early Hodgkin's disease have a normal response and those with systemic symptoms a significantly reduced response. Throughout the course of the disease, the lymphocyte response is associated with the severity of the disease and may show improvement in periods of clinical remission arising from treatment.
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