Abstract
Luteophanol D (1), a new polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Luteophanol D (1) possesses two tetrahydropyran rings and twenty-three hydroxyl groups on C63-linear aliphatic chain with one exo-methylene and two methyl branches.
Highlights
During our continuing search for structurally unique secondary metabolites from marine dinoflagellates, we have isolated a series of cytotoxic macrolides, amphidinolides, as well as long chain polyhydroxyl metabolites from dinoflagellates Amphidinium sp. [1]
We previously investigated a strain of Amphidinium sp., which was isolated from the inside cells of the Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris, and isolated polyhydroxyl metabolites, luteophanols A ~ C [2,3]
The dinoflagellate was unialgally cultured at 25 °C for two weeks in seawater medium enriched with 1% ES supplement
Summary
During our continuing search for structurally unique secondary metabolites from marine dinoflagellates, we have isolated a series of cytotoxic macrolides, amphidinolides, as well as long chain polyhydroxyl metabolites from dinoflagellates Amphidinium sp. [1]. During our continuing search for structurally unique secondary metabolites from marine dinoflagellates, we have isolated a series of cytotoxic macrolides, amphidinolides, as well as long chain polyhydroxyl metabolites from dinoflagellates Amphidinium sp. We previously investigated a strain of Amphidinium sp. (strain number Y-52), which was isolated from the inside cells of the Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris, and isolated polyhydroxyl metabolites, luteophanols A ~ C [2,3]. Further investigation of extracts of the cultured dinoflagellate (Y-52) led to the isolation of a new polyhydroxyl metabolite, luteophanol D (1), possessing two tetrahydropyran rings and twenty three hydroxy groups on C63-linear aliphatic chain. In this paper we describe the isolation and structure elucidation of 1
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