Abstract
Amphezonol A ( 1), a novel polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from an Okinawan marine acoel flatworm Amphiscolops sp. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Amphezonol A ( 1) possesses one tetrahydrofuran ring, two tetrahydropyran rings, and twenty-one hydroxyl groups on C 60-linear aliphatic chain with one exo-methylene and one methyl branch. Amphezonol A ( 1) exhibited a modest inhibitory activity against DNA polymerase α.
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