Abstract
AbstractPerfluoroisobutylene (PFIB) is a toxic, potentially lethal pneumoedematogenic gas. An investigation was undertaken to examine the kinetic course of the pulmonary injurious response to PFIB when inhaled by adult Fischer 344 rats for 10-min durations at mass concentrations ranging from 50 to 200 mg/m3. No lung gravimetric increases or histopathological changes were observed after exposure to 50 or 83 mg/m3 concentrations of PFIB. At ≥ 90 mg/m3, overt lung injury that was detectable by lung gravimetric and histopathological changes was observed within hours after the exposures, with the postexposure times or “latency periods” prior to onset of these responses being inversely related to exposure mass concentration. Latency periods occurring after exposure to 100, and 110 mg/m3 were ∼8 and 4 hr, respectively. No latency period was observed following the exposure of rats to 200 mg/m3. The ultimate severity of the pulmonary injurious response to PFIB increased with increasing exposure mass concentration....
Published Version
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