Abstract
The purpose of this study was to investigate an association between lung hyperinflation and the risk of bone fracture in patients with chronic obstructive pulmonary disease (COPD).Methods. The study involved 125 smokers with COPD. The patients treated with systemic steroids were excluded from the study. Lung function and bone mineral density were measured in all the patients. The risk of osteoporotic bone fractures was calculated by FRAX tool.Results. Lung hyperinflation increased according to the COPD stage. The highest total lung capacity (TLC) was observed in patients with 4 stage COPD (131.43 ± 38.99%pred.) followed by 126.68 ± 21.58%pred. in 3 stage COPD and 115.39 ± 23.68%pred. in 2 stage COPD (p < 0.05). The highest risk of hip fracture (> 3) was calculated for 24.24% of patients with residual lung volume (RV) < 200%pred. and for 45.71% of patients with RV > 200%pred. Conclusions. The risk of hip fracture was significantly associated with the severity of hyperinflation in COPD patients. The highest risk of fractures was found in patients with 4 stage COPD.
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