Abstract
Metal-organic framework (MOF) thin films are receiving increasing attention in a number of different application fields, such as optoelectronics, gas separation, catalysis electronic devices, and biomedicine. In particular, their tunable composition and structure, accessible metal sites and potential for post-synthetic modification for molecular recognition make MOF thin films promising candidates for biosensing applications. Compared with solution-based powdery probes, film-based probes have distinct advantages of good stability and portability, tunable shape and size, real-time detection, non-invasion, extensive suitability in gas/vapor sensing, and recycling. In this review, we summarize the recent advances in luminescent MOF thin films, including the fabrication methods and origins of luminescence. Specifically, luminescent MOF thin films as biosensors for temperature, ions, gases and biomolecules are highlighted.
Highlights
The use of biosensors to detect and quantify the presence of targeted compounds is of great significance in diverse fields, such as medicine, pharmacology, agriculture and food safety, environmental monitoring, industry, defense, homeland security, etc
Metal-organic framework (MOF) sensors have several key advantages over other potential luminescent probe materials: (1) MOFs possess immense potential for tunability and functionalization by altering the metal ions and organic ligands; (2) the inherent crystallinity of MOFs permits exact knowledge of the interactions that may be involved in the detection of analytes; (3) the porosity of MOFs can support the adsorption of analytes into the MOF pores, which can result in preconcentration of the analyte and close-interactions between the MOF and analyte species; (4) the porous frameworks allow the introduction of analyte-selective guest molecules through post synthetic modification into MOF structures for specific recognition
We firstly summarized the main methods for fabrication of MOF thin films followed by a brief introduction of the origins of MOF film luminescence
Summary
The use of biosensors to detect and quantify the presence of targeted compounds is of great significance in diverse fields, such as medicine, pharmacology, agriculture and food safety, environmental monitoring, industry, defense, homeland security, etc. Metal–organic frameworks (MOFs), known as porous coordination polymers (PCPs), which are constructed by the self-assembly of metal ions or clusters and organic ligands, have been widely explored as biosensors because of the unique luminescent properties, diverse advantages from structural and functional components, low biotoxicity, and easy preparation in thin films [18,19,20]. MOF sensors have several key advantages over other potential luminescent probe materials: (1) MOFs possess immense potential for tunability and functionalization by altering the metal ions and organic ligands; (2) the inherent crystallinity of MOFs permits exact knowledge of the interactions that may be involved in the detection of analytes; (3) the porosity of MOFs can support the adsorption of analytes into the MOF pores, which can result in preconcentration of the analyte and close-interactions between the MOF and analyte species; (4) the porous frameworks allow the introduction of analyte-selective guest molecules through post synthetic modification into MOF structures for specific recognition. This review would serve as a guide to better understand and cultivate the design strategies of luminescent MOF film sensors with high sensitivity, selectivity, stability and portability
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