Abstract
Applications of two laser-based quasi-elastic light scattering instruments to the characterization of aerodynamic diameter, diffusion diameter, and electrostatic charge of respirable particles for estimating lung retention of inhaled particles are discussed. The methods provide means of real time, noninvasive in-situ measurements of the size and charge distributions of both inspired and expired particles, permitting quantitative determination of the lung retention of inhaled particles. The two instruments used are: 1) electrical single particle aerodynamic relaxation time (E-SPART) analyzer; and 2) photon correlator employing a dual-beam laser Doppler velocimeter. Both have advantages over the conventional optical particle counter in that they measure equivalent diameter and electrostatic charge independent of the optical scattering properties of the particles, while providing data on a single particle basis. Applications of these instruments in estimating health hazards from atmospheric pollutants and in evaluating the efficacy of therapeutic aerosols in treating diseases are briefly discussed.
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