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Abstract
Purpose: To evaluate the protective effects of Cuminum cyminum Linn (Apiaceae, CCY) against 1- methyl-4 phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced oxidative stress and behavioral impairments in mouse model of Parkinson’s disease (PD).Methods: MPTP-intoxicated mice model of PD was used for evaluating the effect of CCY extract on behavioral deficits through rota rod, passive avoidance and open field tasks. The effect of CCY extract on oxidative stress levels were assessed by estimating enzyme status, including superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation(LPO) in brain tissues of MPTP-induced mice.Results: MPTP (25 mg/kg, i.p.)-treated mice resulted in a significant (p < 0.001) behavioral deficit in locomotor behavior (from 56.24 ± 1.21 to 27.64 ± 0.94) and cognitive functions (from 298 ± 3.68 s to 207.28 ± 4.12 s) compared with their respective control groups. Administration of CCY extract (100, 200 and 300 mg/kg, p.o.) for three weeks significantly and dose-dependently improved (p < 0.001 at 300 mg/kg) locomotor and cognitive deficits in MPTP-treated mice. CCY treatment also significantly (p < 0.001 at 300 mg/kg) inhibited MPTP-induced decrease in antioxidant enzyme levels (superoxide dismutase and catalase) and lipid peroxides in mice brain tissues.Conclusion: CCY extract exhibits strong protection against MPTP-induced behavioral deficit through enhancement of antioxidant defense mechanisms. Therefore, CCY may be developed as a therapeutic strategy in the treatment of neurodegeneration seen in PD.Keywords: Cuminum cyminum, Neurodegeneration, Catalase, Superoxide dismutase, Oxidative stress, Parkinson’s disease
Highlights
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra (SN) region of the brain [1]
The latency to enter the dark compartment was significantly decreased 24 h after foot shock in MPTP-treated mice compared with control mice
The findings of this study indicate that CCY extract attenuates MPTP-induced cognitive and behavioural impairments in mouse model of PD
Summary
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra (SN) region of the brain [1]. C. cyminum was reported to exhibit potent immunomodulatory, nephroprotective, anti-stress and memory enhancing properties [8,9,10] Their protective effect in neurodegenerative disorders such as PD has not been studied. The protective effect of C. cyminum against MPTP-induced behavioral deficits in mouse model of PD was investigated. In addition the effect of CCY on the antioxidant enzyme status in MPTP-induced mouse brain tissues was evaluated to correlate its neuroprotective effect. A step through type passive avoidance test apparatus (GEMINI, Model PACS-30, San Diego instruments Int., USA) was used to evaluate the effects of CCY extract on learning and memory as described previously [17]. Mice were placed initially in the light chamber with the door open They displayed exploratory behavior, and entered the dark compartment.
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