Abstract

Basal ganglia vulnerability to oxidative stress.

Highlights

  • Increased levels of oxidative stress (OS) in the brain have been linked to the etiology of several neurodegenerative diseases, e.g., Alzheimer’s and Parkinson’s disease (Navarro and Boveris, 2009; Melo et al, 2011; Radak et al, 2011; Sultana et al, 2013)

  • In a follow up study the striatum of essential fatty acid (EFA) depleted rats (F2) showed affects at 90–110 days of age (Cardoso et al, 2013). These results indicate that corpus striatum (CS) resilience to OS is only present in the young animals

  • Arachinoid acid (AA), docosahexaenoic acid (DHA), and other polyunsaturated fatty acids (PUFAs) are incorporated into the phospholipids of membranes, where their effect on membrane fluidity affects the functions of membrane transporters, channels and receptors (Yehuda et al, 2002; Schmitz and Ecker, 2008)

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Summary

Introduction

Increased levels of oxidative stress (OS) in the brain have been linked to the etiology of several neurodegenerative diseases, e.g., Alzheimer’s and Parkinson’s disease (Navarro and Boveris, 2009; Melo et al, 2011; Radak et al, 2011; Sultana et al, 2013). A commentary on Differential vulnerability of substantia nigra and corpus striatum to oxidative insult induced by reduced dietary levels of essential fatty acids by Cardoso, H. EFA deprived rats over two generations display reduced numbers and size of dopaminergic neurons in the substantia nigra (SN) (Passos et al, 2012).

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