Lt;emgt;in-vitrolt;/emgt; studies on the inhibition of alpha;-amylase and alpha;-Glucosidase by methanolic extract of lt;emgt;Lawsonia inermislt;/emgt; and lt;emgt;Malvastrum coromandelianumlt;/emgt;

Abstract

Lawsonia inermis and Malvastrum coromandelianum important medicinal plants widely used in India as folk medicine. These plants have been used to control diabetes in traditional medicinal systems. In the present study, 50% volume per volume ethanolic extracts of Lawsonia inermis and Malvastrum coromandelianum subjected to in vitro analysis of antidiabetic effect by alpha-amylase and alpha-glucosidase inhibitory assay. Inhibitory activity of the hydro-ethanolic extract of the all two plants individually against alpha-amylase enzyme and alpha-glucosidase enzyme were examined in different concentrations (3.90–500 μg/mL), where acarbose used as a positive control. The percentage inhibition of Lawsonia inermis showed the highest alpha-amylase and alpha‑glucosidase inhibitory activity. Half-maximal inhibitory concentration value Malvastrum coromandelianum was found for two plants have antidiabetic property, from these two plants Malvastrum coromandelianum showed potent enzyme inhibition as compared to other plant extracts and standard acarbose.