Abstract
The mammalian testis is a complex organ with endocrine and exocrine functions. It consists of seminiferous tubules where the production of the male gametes called spermatogenesis occurs. This process is influenced by a number of factors including the use of physical performance-enhancing drugs. The objective of this study was to evaluate the effects of the anabolic steroid nandrolone decanoate on the morphofunctional structure of testes in sedentary rats and rats subjected to moderate aerobic exercise training. Twenty-four male rats were divided into four experimental groups: sedentary control, sedentary treated, trained control and trained treated.The training lasted eight weeks and consisted of running on a programmable ergometer treadmill, tailored to train eight rats simultaneously. Treated animals received intramuscular injections of nandrolone decanoate (0.5 mg kg -1 body weight) during the last four weeks of physical training, while the control groups received intramuscular injections of vehicle (vegetable oil).The male reproductive system morphology showed that treatment with nandrolone decanoate, in both sedentary and trained rats, promoted morphological and functional changes that result in reduced efficiency of spermatogenesis.
Highlights
The use of physical performance-enhancing drugs is an issue increasingly discussed throughout the world
Taking into consideration that nandrolone decanoate is one of the most widely used anabolic steroidsand that it can interfere with spermatogenesis (FOLETTO et al, 2010) we aimed to evaluate the effects of anabolic androgenic steroids (AAS) administration in Wistar rats submited to physical training at testicular morphophysiology
Assessing the effect of training, it appears that trained animals had a higher testicular weight, compared to sedentary animals; this difference was only significant between the groups treated with anabolic steroid
Summary
The use of physical performance-enhancing drugs is an issue increasingly discussed throughout the world. Their importance is no longer restricted to high-level competitive sport, reaching the areas of recreational sport and physical activity in general. In order to get a better physical performance and muscular appearance, Acta Scientiarum. Health Sciences many young people seek resources that, in most cases, can bring harm to health, such as the indiscriminate use of anabolic androgenic steroids (AAS) (MARQUES et al, 2003; MIRKHANI et al, 2005). AAS are a group of natural and synthetic compounds formed by testosterone and its derivatives (CUNHA et al, 2004; THIBLIN; PETERSSON, 2005).
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