Abstract
Anabolic androgenic-steroids (AAS) include a broad class of synthetic derivatives of testosterone, being nandrolone decanoate the most widely used in sports environment. The aim of this study was to evaluate the metabolic effects of nandrolone decanoate in sedentary and trained adult male rats. We established four experimental groups: sedentary control, sedentary treated, trained control and trained treated. The training had consisted of running on a treadmill for nine weeks. Treated animals received intramuscular injections of nandrolone decanoate (0.5 mg kg -1 ) during the last four weeks of physical training. The training time as the drug used were not sufficient to significantly reduce body weight gain, but caused a significative decrease on diameter of adipocytes and in the amount of adipose tissue stored, as well as decreased the plasma levels of glucose and total cholesterol.
Highlights
Anabolic steroids or androgenic anabolic steroids (AAS) are hormones which show both anabolic – promote an increase of skeletal muscle mass – and androgenic masculinizing effects (HANDELSMAN, 2004; KANAYAMA et al, 2008).It is common to use the term anabolic steroid for any synthetic steroid derivative of testosterone with anabolic activity higher than androgenic activity (SILVA et al, 2002)
This study evaluated the effects of chronic use of nandrolone decanoate on metabolic parameters and morphometry of adipose tissue in sedentary male Wistar rats submitted to physical training
Values statistically different between the experimental groups were not found, the trained group treated with nandrolone (TTr) had a final body weights 12% lower than the sedentary control group (SCo) (Table 1)
Summary
Anabolic steroids or androgenic anabolic steroids (AAS) are hormones which show both anabolic – promote an increase of skeletal muscle mass – and androgenic masculinizing effects (HANDELSMAN, 2004; KANAYAMA et al, 2008). It is common to use the term anabolic steroid for any synthetic steroid derivative of testosterone with anabolic activity higher than androgenic activity (SILVA et al, 2002). These groups of synthetic compounds have been developed for various therapeutic applications: treatment of hypogonadism, neonatal micropenis, growth retardation, and partial androgen deficiency in elderly men or in male hormonal contraception problems. Elite athletes or gym practitioners, attracted by the anabolic effects make use of these compounds (FRIZON et al, 2005)
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