<sup></sup>Determination of Doxorubicin Based on Luminescence Resonance Energy Transfer of NaYF<sub>4</sub>:Yb,Tm Nanoparticles

Abstract

NaYF4:Yb,Tm nanoparticles possessing blue upconversion emission were prepared by microwave-assisted solvothermal method, and used as the donor to set up a luminescence resonance energy transfer system with doxorubicin for rapid detection of doxorubicin. There was a linear relationship of I = 4.98×102 - 9.92C (R = 0.9995) between luminescent intensity and concentration of doxorubicin in the range of 0-66.23 mmol·L-1. A detection limit of 0.69 mmol·L-1 (3s) was obtained by the LRET system with a RSD of 1.6% (60 mmol·L-1 , n=11). This approach is expected to be used for the clinical detection of doxorubicin in medicine.