Abstract
Lysine specific demethylase 1 (LSD1) represents a promising epigenetic target in the treatment of Acute Myeloid Leukemia (AML) and inhibition of LSD1 has been shown to facilitate a response of AML cells to all-trans retinoic acid (ATRA). In this project, we have now modeled the effect of pharmacological or genetic inactivation of LSD1 in two different murine leukemia models based on the retroviral overexpression of either Hoxa9/Meis1 (H/M) or MN1. We transformed bone marrow cells from conditional LSD1 knock-out (KO) mice.
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