LPS, IL-1β or U. parvum-induced chorioamnionitis shows pro-inflammatory signatures in amniotic fluid and placental tissue

Abstract

Historically, chorioamnionitis has been thought to result from ascending microbes driving inflammation of the chorioamnion, and is associated with PTB, perinatal morbidity, and adverse fetal outcomes. However, pathophysiology studies in humans suggest that it results from focal membrane colonization. Here, we studied the extent and spread of chorioamnionitis in non-human primates induced by sterile intraamniotic injection (IA) of IL1β, LPS, or Ureaplasma parvum (UP).