Abstract
Low-intensity pulsed ultrasound stimulation (LIPUS) can inhibit seizures associated with temporal lobe epilepsy (TLE), which is the most common epileptic syndrome in adults and accounts for more than half of the cases of intractable epilepsy. Electroencephalography (EEG) signal analysis is an important method for studying epilepsy. The nonlinear dynamics of epileptic EEG signals can be used as biomarkers for the prediction and diagnosis of epilepsy. However, how ultrasound modulates the nonlinear dynamic characteristics of EEG signals in TLE is still unclear. Here, we used low-intensity pulsed ultrasound to stimulate the CA3 region of kainite (KA)-induced TLE mice, simultaneously recorded local field potentials (LFP) in the stimulation regions before, during, and after LIPUS. The nonlinear characteristics, including complexity, approximate entropy of different frequency bands, and Lyapunov exponent of the LFP, were calculated. Compared with the control group, the experimental group showed that LIPUS inhibited TLE seizure and the complexity, approximate entropy of the delta (0.5–4 Hz) and theta (4–8 Hz) frequency bands, and Lyapunov exponent of the LFP significantly increased in response to ultrasound stimulation. The values before ultrasound stimulation were higher ∼1.87 (complexity), ∼1.39 (approximate entropy of delta frequency bands), ∼1.13 (approximate entropy of theta frequency bands) and ∼1.46 times (Lyapunov exponent) than that after ultrasound stimulation (p < 0.05). The above results demonstrated that LIPUS can alter nonlinear dynamic characteristics and provide a basis for the application of ultrasound stimulation in the treatment of epilepsy.
Highlights
Epilepsy is one of the most common neurological diseases in the world
We first proved that Low-intensity pulsed ultrasound stimulation (LIPUS) can inhibit Temporal lobe epilepsy (TLE) seizures
Our results demonstrated that lowintensity ultrasound can effectively modulate nonlinear dynamics in TLE
Summary
Epilepsy is one of the most common neurological diseases in the world. The reason for epileptic seizures is the sudden abnormal firing of neurons. There are transient dysfunctions in the brain that trigger short-term obstacles in patient movement and consciousness (Bjørk et al, 2015; Robertson et al, 2015; Xu et al, 2016). Lesions in different parts of the brain cause different. LIPUS Modulates Biomarkers of LFP in TLE types of epilepsy, and there is no one brain area associated with all types of epilepsy. Temporal lobe epilepsy (TLE) is the most common epileptic syndrome in adults and accounts for more than half of the cases of intractable epilepsy. TLE has the characteristics of frequent seizures and difficult diagnosis and treatment (Monti and Meletti, 2015; Lévesque et al, 2016; Steinhäuser et al, 2016)
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