Abstract
Objective: Initial randomized controlled trials (RCTs) and recently released systematic reviews have identified resistance training (RT) as a modality to manage motor symptoms and improve physical functioning in individuals with Parkinson's disease (PD), although the effects are inconsistent. Therefore, we conducted an updated meta-analysis to reassess the evidence of the relationship.Methods: We performed a systematic search of studies reporting the effects of RT in PD available through major electronic databases (PubMed, Medline, Embase, Ovid, Cochrane Library, CNKI, Wanfang) through 20 July 2020. Eligible RCTs were screened based on established inclusion criteria. We extracted data on the indicators of leg strength, balance, gait capacity, and quality of life (QoL) of lower limbs. Random and fixed effects models were used for the analysis of standard mean differences (SMD) or mean differences (MD) with their 95% confidence intervals (CI).Results: Thirty-one papers from 25 independent trials compromising 1,239 subjects were selected for eligibility in this systematic review and meta-analysis. Summarized data indicated that the leg strength increased statistically significant in PD patients (SMD = 0.79, 95% CI 0.3, 1.27, P = 0.001), the balance capability was improved statistically significant in PD patients (SMD = 0.34, 95% CI 0.01, 0.66, P = 0.04), and QoL statistically significantly improved (MD = −7.22, 95% CI −12.05, −2.39, P = 0.003). For gait performance, four indicators were measured, the results as follows: fast gait velocity (MD = 0.14, 95% CI 0.06, 0.23, P = 0.001), Timed-up-and-go-test (TUG, MD = −1.17, 95% CI −2.27, −0.08, P = 0.04) and Freezing of Gait Questionnaire (FOG-Q, MD = −1.74, 95% CI −3.18, −0.3, P = 0.02) were improved statistically significant across trials, while there were no statistically significant improvement in stride length (MD = −0.05, 95% CI −0.12, 0.02, P = 0.15) in PD patients.Conclusions: Lower limb RT has positive effects during rehabilitation in individuals with PD in leg strength, QoL, and improve gait performance to a certain extent. RT also could improve balance capacity of patients, although a wide variety of tools were used, and further study is needed to confirm these findings.
Highlights
Parkinson’s disease (PD) is a highly prevalent and progressive degenerative disorder of the nervous system, primarily affecting the middle-aged and elderly
The 189 remaining literature were carefully evaluated by full-text review; 92 articles were considered suitable for the inclusion
Thirty one papers compromising 1,239 subjects were selected for eligibility in this systematic review and meta-analysis [7, 9, 10, 13, 16, 17, 23, 26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49]
Summary
Parkinson’s disease (PD) is a highly prevalent and progressive degenerative disorder of the nervous system, primarily affecting the middle-aged and elderly. Clinical symptoms of PD include motor symptoms and non-motor symptoms. The classic tetrad of Parkinson’s symptoms includes—resting tremor, bradykinesia, rigidity, and loss of postural reflexes. These motor difficulties bring about decreased muscle strength and increased tension in the lower limbs, further impairing balance performance and seriously affecting standing and walking postural instability [6]. Postural instability increases the risk of falling and fear of falling, and often results in increased sedentarism, resulting in poor quality of life (QoL) [7, 8]. Depression, neuropsychiatric symptoms, and sleep disturbances, negatively impacting the quality in patients with PD life in addition to the motor symptoms [9, 10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
