Low-Trauma Non-Vertebral Fractures In Ukrainian Postmenopausal Women With Obesity And Metabolic Syndrome

Abstract

Introduction Osteoporosis and obesity are two of the worldwide problems, which increase morbidity, disability and mortality among people. Abdominal obesity leads to the metabolic syndrome (MS) development. It was researched that components of MS have influence on bone mineral density (BMD), but data are contradictory. The aim of this study was to determine freaquency of non-vertebral fractures in women with obesity and MS. Methods 590 women aged 50-79 yrs (mean age – 64.0±8.0 yrs; mean body mass index (BMI) – 29.4±5.3 kg/m2, mean duration of menopause – 14.6±8.4 yrs) were examined. The women were compared into the three groups: A – 298 women without obesity (BMI) ≤ 29.9 kg/m2), B – 177 patients with obesity (BMI ≥ 30.0 kg/m2), C – 115 female with MS (diagnosed according to IDF criteria, 2005 yr). BMD was measured by the DXA method (Prodigy, 2005). Data were analyzed using Statistical Package 6.0. Results We estimated that patients without obesity have significantly lower BMD of lumbar spine (A – 0.931±0.168g/cm2, B – 1.091±0.191g/cm2, C – 1.082±0.,190g/cm2 F=55.302, p The frequency of non-vertebral fractures did not differ significantly in the groups of patients A and B, A and C, B and C (X2=3.107, p>0.05, X2=0.182, p>0.05 and X2=1.041, p>0.05, respectively). Conclusion Despite the fact that BMD indexes were significantly higher in women with metabolic syndrome and obesity, the frequency of non-vertebral fractures did not differ significantly in the groups of patients.