Abstract
BackgroundMortality and complications remain high after acute type A aortic dissection (ATAAD) open surgery and are associated with coagulation dysfunction. Platelets play an important role in the process of coagulation. This study explored the relationship between postoperative platelet counts and 3-year mortality after operation in patients with ATAAD undergoing open aortic repair surgery.MethodsPatients with ATAAD who underwent Total Arch Replacement and Frozen Elephant Trunk in Fuwai Hospital from 2011 to 2015 were selected for this study. The perioperative data were collected and sorted through the electronic clinical case system. Multivariate Logistic regression was used to analyze the risk factors for death within three years after surgery.ResultsA total of 495 patients were included in the analysis. After correction for confounding factors, decreased postoperative platelet count remained an independent factor that was associated with lower mortality (OR = 0.918, 95% CI 0.853–0.988, P = 0.023).ConclusionsThe study indicated that decreased postoperative platelet count may lead to increased 3-year mortality, in patients with ATAAD who underwent open aortic repair surgery.
Highlights
Mortality and complications remain high after acute type A aortic dissection (ATAAD) open surgery and are associated with coagulation dysfunction
Surgery is the primary treatment for acute type A aortic dissection (ATAAD) [5]
ATAAD was defined by observing an intimal flap separating 2 lumina in the ascending aorta that occurred within 14 days of symptom onset [16]
Summary
Mortality and complications remain high after acute type A aortic dissection (ATAAD) open surgery and are associated with coagulation dysfunction. This study explored the relationship between postoperative platelet counts and 3-year mortality after operation in patients with ATAAD undergoing open aortic repair surgery. Surgery is the primary treatment for acute type A aortic dissection (ATAAD) [5]. The incidence of surgical complications, such as postoperative cerebral infarction and reoperation for bleeding, is high. One of the causes of poor prognosis is abnormal perioperative coagulation function. Surgical trauma, which is unavoidable, is an essential factor in coagulation disorders. When an injury such as surgery causes bleeding, platelets play a crucial role in hemostasis. Platelets can activate, secrete, and interact with coagulation factors [13, 14]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call