Low melting mixture glycerol:proline as an innovative designer solvent for the synthesis of novel chromeno fused thiazolopyrimidinone derivatives: An excellent correlation with green chemistry metrics

Abstract

The expansion of proficient and environmentally benign synthetic protocols has engrossed increasing attention in recent organic syntheses in view of the mounting concern over the environment. As part of this green concept, our group designed novel LTTM by using Glycerol and proline (1:1) at reflux condition, and effectiveness of novel DES or LTTM has been studied for the synthesis of 7-(aryl)-10-methyl-6H,7H-chromeno[4,3-d]thiazolo[3,2-a]pyrimidin-6-one derivatives via Multicomponent reaction. The synthetic methodology with the use of novel LTTM as green solvent and inexpensive, biodegradable, plays a dual role (recyclable catalyst and solvent) with its operational simplicity and maximum greener synthetic efficiency with green chemistry metrics calculations will be attractive for academic and industrial research. The synthesized derivatives have been evaluated for mosquito larvicidal bioassay using two mosquito species namely Aedes aegypti and Culex quinquefasciatus.